HARMA FARMAKON

BUPRENORPHINE
Name: BUPRENORPHINEClass: Narcotic Agonist-Antagonist AnalgesicRisk Factor: CM
Buprenorphine, an analgesic that possesses both narcotic agonist and antagonist activity, is approximately 33 times more potent than morphine (0.3 mg buprenorphine is equivalent to 10 mg morphine in analgesic and respiratory depressant effects). Although a sublingual formulation is available in other countries, only parenteral buprenorphine has been approved for general use in the United States. The human adult dose is 0.3–0.6 mg IM or IV repeated up to every 6 hours (0.017– 0.034 mg/kg/day for a 70-kg person).